Journal Article

Detection of Lysergic Acid Diethylamide (LSD) in Urine by Gas Chromatography-Ion Trap Tandem Mass Spectrometry*

Jason H. Sklerov, Kathryn S. Kalasinsky and Cheryl A. Ehorn

in Journal of Analytical Toxicology

Volume 23, issue 6, pages 474-478
Published in print October 1999 | ISSN: 0146-4760
Published online October 1999 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/23.6.474
Detection of Lysergic Acid Diethylamide (LSD) in Urine by Gas Chromatography-Ion Trap Tandem Mass Spectrometry*

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A confirmatory method for the detection and quantitation of lysergic acid diethylamide (LSD) is presented. The method employs gas chromatography-tandem mass spectrometry (GC-MS-MS) using an internal ionization ion trap detector for sensitive MS-MS-in-time measurements of LSD extracted from urine. Following a single-step solid-phase extraction of 5 mL of urine, underivatized LSD can be measured with limits of quantitation and detection of 80 and 20 pg/mL, respectively. Temperature-programmed on-column injections of urine extracts were linear over the concentration range 20–2000 pg/mL (r2 = 0.999). Intraday and interday coefficients of variation were < 6% and < 13%, respectively. This procedure has been applied to quality-control specimens and LSD-positive samples in this laboratory. Comparisons with alternate GC-MS methods and extraction procedures are discussed.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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