Journal Article

Elimination Half-Life of Acetone in Humans: Case Reports and Review of the Literature

A.W. Jones

in Journal of Analytical Toxicology

Volume 24, issue 1, pages 8-10
Published in print January 2000 | ISSN: 0146-4760
Published online January 2000 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/24.1.8
Elimination Half-Life of Acetone in Humans: Case Reports and Review of the Literature

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Two instances of finding abnormally high concentrations of acetone in urine (0.10 g/dL and 0.052 g/dL) without any measurable amounts of ethanol (< 0.005 g/dL) or isopropanot (< 0.005 g/dL) prompted a survey of the elimination kinetics of isopropanol and its metabolite acetone in humans. In a hospital patient who had ingested denatured alcohol, the elimination half-life (t½) of acetone during detoxification was 27 h and not 3–5 h as reported by other workers. Several other literature reports of individuals who had ingested isopropanol as well as controlled studies after administration of moderate amounts of acetone and/or isopropanol support the notion of a long elimination half-life of 17–27 h for acetone compared with a t½ of 1–3 h for isopropanol.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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