Journal Article

Evaluation of Testosterone/Epitestosterone Ratio Influential Factors as Determined in Doping Analysis

D.H. van de Kerkhof, D. de Boer, J.H.H. Thijssen and R.A.A. Maes

in Journal of Analytical Toxicology

Volume 24, issue 2, pages 102-115
Published in print March 2000 | ISSN: 0146-4760
Published online March 2000 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/24.2.102
Evaluation of Testosterone/Epitestosterone Ratio Influential Factors as Determined in Doping Analysis

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The ratio of the concentration of testosterone glucuronide to the concentration of epitestosterone glucuronide (T/E ratio) as determined in urine is the most frequently used method to prove testosterone abuse by athletes. A T/E ratio higher than 6 has been considered as proof of abuse in the past; however, cases of naturally occurring higher T/E ratios have been described. Since the introduction of the T/E ratio in doping analysis, the parameters that may or may not influence the T/E ratio, possibly leading to false-positive results, have been debated. To achieve more insight on the influencing circumstances, an overview is given to obtain an objective view on the merits of the urinary T/E ratio. Relevant analytical aspects of the T/E ratio, potential parameters of endogenous and exogenous origins, as well as some alternative methods to determine testosterone abuse, such as the urinary testosterone/luteinizing hormone ratio, gas chromatography-combustion-isotope-ratio mass spectrometry, hair analysis, and high-performance liquid chromatography-mass spectrometry, are discussed.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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