Journal Article

The Determination of Δ<sup>9</sup>-Tetrahydrocannabinol and 11-Nor-9-Carboxy-Δ<sup>9</sup>-tetrahydrocannabinol in Whole Blood Using Solvent Extraction Combined with Polar Solid-Phase Extraction

Peter D. Felgate and Andrew C. Dinan

in Journal of Analytical Toxicology

Volume 24, issue 2, pages 127-132
Published in print March 2000 | ISSN: 0146-4760
Published online March 2000 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/24.2.127
The Determination of Δ9-Tetrahydrocannabinol and 11-Nor-9-Carboxy-Δ9-tetrahydrocannabinol in Whole Blood Using Solvent Extraction Combined with Polar Solid-Phase Extraction

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A method for the determination of Δ9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) in whole blood using conventional solvent extraction followed by a cleanup using polar solid-phase cartridges is described. The method uses 0.5 mL of blood, and detection is by benchtop gas chromatography-mass selective detection using selected ion monitoring. The limit of detection is better than 1 ng/mL, and extraction efficiencies are greater than 80% for THC and 70% for THCCOOH. The method is robust and highly reproducible.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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