Journal Article

Over-the-Counter Δ<sup>5</sup> Anabolic Steroids 5-Androsten-3,17-dione; 5-Androsten-3β, 17β-diol; Dehydroepiandrosterone; and 19-Nor-5-androsten-3,17-dione: Excretion Studies in Men*

Victor P. Uralets and Paul A. Gillette

in Journal of Analytical Toxicology

Volume 24, issue 3, pages 188-193
Published in print April 2000 | ISSN: 0146-4760
Published online April 2000 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/24.3.188
Over-the-Counter Δ5 Anabolic Steroids 5-Androsten-3,17-dione; 5-Androsten-3β, 17β-diol; Dehydroepiandrosterone; and 19-Nor-5-androsten-3,17-dione: Excretion Studies in Men*

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Studies of urinary steroids were performed in males after oral administration of 5-androsten-3,17-dione; 5-androsten-β, 17β-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3, 17-dione. 5-Androsten-3,17-dione; 5-androsten-3β,17β-diol; and dehydroepiandrosterone amplify most endogenous steroids, but to a lesser extent than their Δ4 analogues do. Especially affected are androsterone, etiocholanolone, dehydroandrosterone, dehydroepiandrosterone, and isomeric 5-androstendiols. 5-Androsten-3,17-dione; 5-androsten-3β,17β-diol; and dehydroepiandrosterone elevate the urinary testosterone to epitestosterone (T/E) ratio by a factor of 2–3 a few hours after administration. This may cause a positive T/E test (> 6) for individuals with normal T/E ratios higher than 2. Most of the steroids return to their original concentrations in less than 24 h. Etiocholanolone and 5β-androstan-3α,17β-diol remain elevated for several days. A reduced androsterone to etiocholanolone (A/E) ratio may be an indication of Δs steroids abuse. 19-Nor-5-androsten-3,17-dione has a similar effect, except that all metabolites in urine are 19-nor exogenous steroids. Identification criteria for 19-nor-5-androsten-3,17-dione may be the same as nandrolone, that is, detection of 19-norandrosterone and 19-noretiocholanolone. Specific abundant metabolites of 19-nor-5-androsten-3,17-dione are 19-nordehydroandrosterone and 19-nordebydroepiandrosterone. In the later stages of excretion, higher concentration of 19-noreticholanolone relative to 19-norandrosterone specifically indicates administration of 19-nor Δ5 steroids.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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