Journal Article

Using Amphetamine Isomer Ratios to Determine the Compliance of Amphetamine Abusers Prescribed Dexedrine

S. George and R.A. Braithwaite

in Journal of Analytical Toxicology

Volume 24, issue 3, pages 223-227
Published in print April 2000 | ISSN: 0146-4760
Published online April 2000 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/24.3.223
Using Amphetamine Isomer Ratios to Determine the Compliance of Amphetamine Abusers Prescribed Dexedrine

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The amphetamine isomer ratios (l-amphetamine/d-amphetamine) in 373 urine specimens submitted for analysis over a two-year period have been determined using a chiral derivatizing agent in conjunction with a gas chromatograph fitted with a nitrogen-specific detector. All of the specimens were collected from known or suspected amphetamine abusers, some of which were prescribed dexedrine for maintenance and detoxification. The mean (± 1 standard deviation [SD]) l/d-amphetamine isomer ratio for 147 specimens from compliant subjects prescribed dexedrine was 15.0% (± 4.9%). The mean (± 1 SD) l/d-amphetamine isomer ratio from 165 subjects abusing illicit amphetamine was 98.5 (± 27.5%). The calculation of l/d-amphetamine isomer ratios in urine has been found to be a rapid method for determining the compliance of subjects prescribed dexedrine and is therefore a useful technique for the continued management of amphetamine abusers. In addition, 17 specimens of illicit amphetamine powder (assumed to be a racemic mixture) were submitted to the laboratory for analysis. Using a combination of gas chromatography with and without chiral derivatization, the powders were found to have a mean l/d-amphetamine isomer ratio of 89.2% (range 72.2% to 98.3%) and mean purity (w/w) of 21.5% (range 3.4% to 71.0%) relative to pure dl-amphetamine substance.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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