Journal Article

Retrospective Study of Urinalysis for <i>dl</i>-Amphetamine and <i>dl</i>-Methamphetamine Analysis under Current Department of Defense Guidelines

Ronald L. Shippee and Donald J. Kippenberger

in Journal of Analytical Toxicology

Volume 24, issue 6, pages 450-452
Published in print September 2000 | ISSN: 0146-4760
Published online September 2000 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/24.6.450
Retrospective Study of Urinalysis for dl-Amphetamine and dl-Methamphetamine Analysis under Current Department of Defense Guidelines

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Under current Department of Defense (DOD) directive, the laboratories certified to conduct urinalyis testing in support of the DOD Drug Deterrence Program are required to conduct dl-isomer analysis on all specimens that confirm at a concentration greater than 500 ng/mL methamphetamine (METH). Although the same cutoff concentration is required for amphetamine (AMP) reporting, there is no requirement for dl-isomer analysis of AMP-positive specimens. Of the 894,823 specimens screened by the Army Drug Testing Laboratory at Ft. Meade, MD during a 19-month period, 339 confirmed positive for METH. From this positive population, seven specimens failed to confirm at or above the DOD cutoff of > 20% d-isomer. One of the seven specimens contained 534 ng/mL l-AMP and was reported positive for AMP. Although 100% of the AMP was the l-isomer, under current DOD directive, this information was not passed along to the Medical Review Officers (MRO) to assist them during the interview process. Although this situation appears to be a rare event, consideration should be given to requiring dl-isomer analysis of AMP-positive specimens and forwarding this information to the MRO.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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