Journal Article

<sup>1</sup>H NMR Spectroscopic Investigation of Serum and Urine in a Case of Acute Tetrahydrofuran Poisoning

Bernard Cartigny, Nathalie Azaroual, Michel Imbenotte, Nouredine Sadeg, Francine Testart, Jack Richecoeur, Gaston Vermeersch and Michel Lhermitte

in Journal of Analytical Toxicology

Volume 25, issue 4, pages 270-274
Published in print May 2001 | ISSN: 0146-4760
Published online May 2001 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/25.4.270
1H NMR Spectroscopic Investigation of Serum and Urine in a Case of Acute Tetrahydrofuran Poisoning

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This article reports the investigation by 1H nuclear magnetic resonance (1H NMR) spectroscopy of biological fluids in a case of intentional poisoning with tetrahydrofuran (THF). Occupational exposures to this solvent are well documented, but acute poisoning cases are extremely rare, and the one presented here is the second known case of this kind. Urine and serum samples were collected. Without any pretreatment, the presence of THF was confirmed by characteristic resonances at 1.90 and 3.76 ppm; high lactate levels were also observed. The presence of γ-hydroxybutyric acid (GHB) was noted. Quantitative analysis was performed by relative integration of peak areas. THF concentrations were 813 and 850 mg/L (11.3 and 11.8 mmol/L), and GHB concentrations 239 and 2977 mg/L (2.3 and 28.6 mmol/L) in serum and urine, respectively. A gas chromatographic-mass spectrometric method confirmed 1H NMR observations. The origin of GHB detected in serum and urine is also discussed.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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