Journal Article

LC-EI-MS Determination of Veratridine and Cevadine in Two Fatal Cases of <i>Veratrum album</i> Poisoning

Yvan Gaillard and Gilbert Pepin

in Journal of Analytical Toxicology

Volume 25, issue 6, pages 481-485
Published in print September 2001 | ISSN: 0146-4760
Published online September 2001 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/25.6.481
LC-EI-MS Determination of Veratridine and Cevadine in Two Fatal Cases of Veratrum album Poisoning

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We report two fatal poisonings due to the ingestion of plant material. The two deceased were discovered in the water of a mountain lake about one month after the postmortem immersion of the corpses. Macroscopic examination of the stomachs revealed the presence of a very large number of small blackish granules, which were later identified as seeds of a Veratrum species. Veratridine and cevadine were identified and quantitated by high-performance liquid chromatography-electrospray ionization-mass spectrometry. Measured blood concentrations were 0.17 and 0.40 ng/mL for veratridine and 0.32 and 0.48 ng/mL for cevadine. The absence of other toxic substance led to the assumption that this massive ingestion was the cause of death, although the circumstances surrounding intake remained unknown.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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