Journal Article

Three Cases of Fatal Paramethoxyamphetamine Overdose

Teri L. Martin

in Journal of Analytical Toxicology

Volume 25, issue 7, pages 649-651
Published in print October 2001 | ISSN: 0146-4760
Published online October 2001 | e-ISSN: 1945-2403 | DOI: https://dx.doi.org/10.1093/jat/25.7.649
Three Cases of Fatal Paramethoxyamphetamine Overdose

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Two recent cases of death due to paramethoxyamphetamine (PMA), a methoxylated phenylethylamine derivative, are described and compared with a previous PMA death that occurred in this province in 1985. The deceased were 18 or 19 years of age and were reported to have ingested either methylenedioxymethamphetamine (MDMA, Ecstasy) or methylenedioxyamphetamine (MDA) prior to their deaths. Concentrations of PMA were measured in both peripheral and heart blood samples using gas chromatography equipped with a nitrogen-phosphorus detector. PMA results in the most recent cases were 0.6 mg/L and 1.3 mg/L in the peripheral blood samples, and corresponding heart blood samples were 0.7 mg/L and 2.3 mg/L, respectively. In the 1985 case, the femoral blood concentration was 0.6 mg/L, and the heart blood concentration was 0.8 mg/L. Significant differences between heart and peripheral blood concentrations were observed in two of the three cases, which may indicate the potential for postmortem redistribution of PMA.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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