Journal Article

Quantitation of Organophosphorus Nerve Agent Metabolites in Human Urine Using Isotope Dilution Gas Chromatography-Tandem Mass Spectrometry

W. Jack Driskell, Ming Shih, Larry L. Needham and Dana B. Barr

in Journal of Analytical Toxicology

Volume 26, issue 1, pages 6-10
Published in print January 2002 | ISSN: 0146-4760
Published online January 2002 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/26.1.6
Quantitation of Organophosphorus Nerve Agent Metabolites in Human Urine Using Isotope Dilution Gas Chromatography-Tandem Mass Spectrometry

More Like This

Show all results sharing these subjects:

  • Medical Toxicology
  • Toxicology (Non-medical)

GO

Show Summary Details

Preview

An isotope dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method was developed for quantitating the urinary metabolites of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine samples were concentrated by codistillation with acetonitrile, derivatized by methylation with diazomethane, and analyzed by GC-MS-MS. The limits of detection were less than 4 µg/L for all the analytes except for the GA metabolite, which had a limit of detection of less than 20 µg/L.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.