Journal Article

The Simultaneous Determination of Codeine, Morphine, Hydrocodone, Hydromorphone, 6-Acetylmorphine, and Oxycodone in Hair and Oral Fluid

Joseph Jones, Kimberly Tomlinson and Christine Moore

in Journal of Analytical Toxicology

Volume 26, issue 3, pages 171-175
Published in print April 2002 | ISSN: 0146-4760
Published online April 2002 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/26.3.171
The Simultaneous Determination of Codeine, Morphine, Hydrocodone, Hydromorphone, 6-Acetylmorphine, and Oxycodone in Hair and Oral Fluid

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Recently, the abuse of prescription opiates as alternatives to heroin has become a national concern. The determination of a six-drug opiate panel, codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, and oxycodone, in hair and oral fluid using solid-phase extraction and capillary gas chromatography-mass spectrometry (GC-MS) is described. Oral fluid was obtained from the donor by insertion of absorptive collectors into the mouth. Hair was collected from the patient and powdered using stainless steel ball bearings in a mini bead-beater apparatus. Opiates present in the samples were extracted from a buffered, aqueous matrix using a solid-phase cartridge. The extracts were concentrated and the methoxime/BSTFA derivatives prepared in order to eliminate interference from the keto-opiates. The extracts were separated by GC-MS in electron impact mode. By utilizing methoxyamine, we were able to produce the methoxime derivatives required for single derivative production and chromatographically separate all six opiates. The routine analysis of these opiates in hair and oral fluid using GC-MS is described for the first time.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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