Journal Article

LC-MS Determination of Oxydemeton-methyl and Its Main Metabolite Demeton-S-methylsulfon in Biological Specimens—Application to a Forensic Case

J. Beike, Ch. Ortmann, Th. Meiners, B. Brinkmann and H. Köhler

in Journal of Analytical Toxicology

Volume 26, issue 5, pages 308-312
Published in print July 2002 | ISSN: 0146-4760
Published online July 2002 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/26.5.308
LC-MS Determination of Oxydemeton-methyl and Its Main Metabolite Demeton-S-methylsulfon in Biological Specimens—Application to a Forensic Case

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A sensitive method for the identification and quantitation of the organophosphate insecticide oxydemeton-methyl and its metabolite demeton-S-methylsulfon from human blood and various tissue samples has been established. After solid-phase extraction using C18 cartridges the extracts were analyzed by high-performance liquid chromatography with mass selective detection (Finnigan MAT LCQ). The method was completely validated. The limit of detection is 1 ng/g blood for the parent substance oxydemeton-methyl and 2 ng/g blood for the metabolite demeton-S-methylsulfon. This method was applied for the analysis of blood and tissue samples of a 58-year-old man who died after the intake of Metasystox R-Spezial®, a product from Bayer containing oxydemeton-methyl. Because of a prolonged interval between the ingestion and death, the concentrations of oxydemeton-methyl and demeton-S-methylsulfon were very low. Although the body was already putrefied when the autopsy was performed, the chromatograms of blood and tissue samples were free of interfering peaks.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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