Journal Article

Determination of Cobalt in Urine by FI-ICP-AES with Online Preconcentration

Gustavo M. Farias, Rodolfo G. Wuilloud, Susana Moyano, José A. Gásquez, Roberto A. Olsina and Luis D. Martinez

in Journal of Analytical Toxicology

Volume 26, issue 6, pages 360-364
Published in print September 2002 | ISSN: 0146-4760
Published online September 2002 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/26.6.360
Determination of Cobalt in Urine by FI-ICP-AES with Online Preconcentration

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A method for the preconcentration and determination of cobalt in human urine samples was developed. The online preconcentration and determination were attained using inductively coupled plasma atomic emission spectromety (ICP-AES) coupled to a flow injection (FI) method. Cobalt was retained on an Amberlite XAD-7 resin as cobalt-2-(5-bromo-2-pyridylazo)-5-diethylaminophenol complex at pH 9.5. Cobalt was removed from the microcolumn with perchloric acid. A sensitivity enhancement factor of 90 was obtained with respect to cobalt determination by ICP-AES without preconcentration. The value of detection limit for the preconcentration method proposed was 25 ng/L. The precision for 10 replicate determinations at the 5 mg/L (mean ± SD, 5.1 ± 0.14) Co level was 2.7% relative standard deviation, calculated from the peak heights obtained. The calibration graph preconcentration method for cobalt was linear with a correlation coefficient of 0.9994 from approximately 0.25 mg/L up to at least 100 mg/L. The method was successfully applied to the determination of cobalt in human urine samples.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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