Journal Article

Usefulness of Sweat Testing for the Detection of MDMA after a Single-Dose Administration*

Simona Pichini, Monica Navarro, Roberta Pacifici, Piergiorgio Zuccaro, Jordi Ortuño, Magí Farré, Pere Nolasc Roset, Jordi Segura and Rafael de la Torre

in Journal of Analytical Toxicology

Volume 27, issue 5, pages 294-303
Published in print July 2003 | ISSN: 0146-4760
Published online July 2003 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/27.5.294
Usefulness of Sweat Testing for the Detection of MDMA after a Single-Dose Administration*

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Nine healthy male subjects and recreational users of 3,4-methylenedioxymethamphetamine (MDMA) participated in a study aimed to assess the usefulness of sweat testing for the detection of MDMA after a single 100-mg dose. Sweat was collected for up to 24 h with the PharmChek sweat patches from which drugs were eluted and then analyzed by immunoassay and gas chromatography-mass spectrometry using deuterated internal standards. The usefulness of a rapid onsite test, the Drugwipe immunochemical strip test, was also assessed. In the sweat patches, MDMA was detected as early as 1.5 h after consumption and peaked at 24 h. Intersubject variability was large; peak MDMA concentrations for the same dose varied in magnitude 30-fold. MDMA concentrations ranged between 3.2 and 1326.1 ng/patch. Only traces of the minor metabolite 3,4-methylenedioxyamphetamine were detected. In all subjects, the onsite test with the Drugwipe was positive at 1.5 h (peak time of MDMA plasma concentration). However, few false-negative results (18%) appeared in the first 6 h after administration. Both sweat patch testing and the onsite sweat strip test may find useful application for noninvasive monitoring of MDMA abuse in sweat.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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