Journal Article

Detection and Quantitation Analysis of Cocaine and Metabolites in Fixed Liver Tissue and Formalin Solutions

Mariano Cingolani, Marcello Cippitelli, Rino Froldi, Veniero Gambaro and Giovanna Tassoni

in Journal of Analytical Toxicology

Volume 28, issue 1, pages 16-19
Published in print January 2004 | ISSN: 0146-4760
Published online January 2004 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/28.1.16
Detection and Quantitation Analysis of Cocaine and Metabolites in Fixed Liver Tissue and Formalin Solutions

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This study reports the results of the detection and quantitation of cocaine and its metabolites in liver tissues fixed in formalin and in the formalin solutions in which the same tissues were fixed. Toxicological analyses were performed on formalin-fixed liver samples from four cases of death of cocaine abusers and on formalin solutions (10% buffered, pH 7) in which the samples were preserved. Analyses carried out at the time of autopsy on body fluids and tissues allowed identification of cocaine and the metabolite benzoylecgonine. Liver tissue samples were preserved in formalin solutions for four weeks before analysis. Results only showed the presence of benzoylecgonine in the studied materials. The mean levels of recovery of benzoylecgonine in fixed tissues were 12.31% in liver and 84.47% in formalin from liver. Results indicated that benzoylecgonine has good stability, even in biological specimens subjected to chemical fixation.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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