Journal Article

Application of ORAL·screen™ Saliva Drug Test for the Screening of Methamphetamine, MDMA, and MDEA Incorporated in Hair

Akihiro Miki, Munehiro Katagi, Noriaki Shima and Hitoshi Tsuchihashi

in Journal of Analytical Toxicology

Volume 28, issue 2, pages 132-134
Published in print March 2004 | ISSN: 0146-4760
Published online March 2004 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/28.2.132
Application of ORAL·screen™ Saliva Drug Test for the Screening of Methamphetamine, MDMA, and MDEA Incorporated in Hair

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By the use of a one-step immunoassay drug test for oral fluid, a convenient and fairly sensitive screening method has been devised for methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) incorporated in hair. These drugs, in a 10-mg portion of hair, were extracted into 5M HCl/methanol (1:20, v/v), and the extract reconstituted in 100 µL water was assayed with the saliva drug test ORAL·screen. The limits of detection were 0.5 ng/mg hair for d-MA, 0.8 ng/mg for dl-MDMA, and 1.0 ng/mg for dl-MDEA. The results are in good agreement with those of gas chromatography-mass spectrometry (GC-MS) determination. Although all positive results must be confirmed by either GC-MS or a specific alternative methodology, this method provided a simple screening, suitable for drug enforcement purposes, while requiring only a 10-mg hair specimen.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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