Journal Article

A Rapid, Sensitive Method for the Quantitation of Specific Metabolites of Sulfur Mustard in Human Urine Using Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry

Carrie L. Young, Doris Ash, W. Jack Driskell, Anne E. Boyer, Rodolfo A. Martinez, L.A. Silks and John R. Barr

in Journal of Analytical Toxicology

Volume 28, issue 5, pages 339-345
Published in print July 2004 | ISSN: 0146-4760
Published online July 2004 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/28.5.339
A Rapid, Sensitive Method for the Quantitation of Specific Metabolites of Sulfur Mustard in Human Urine Using Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry

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Sulfur mustard agent (HD) (2,2′-dichloroethyl sulfide), a Schedule I compound on the Chemical Weapons Convention Schedule of Chemicals, remains a public health concern because it is simple to synthesize and it is in the chemical weapon stockpiles of several countries. A sensitive, rapid, accurate, and precise method was developed to quantitate trace levels of 1,1′-sulfonylbis [2-(methylthio) ethane] (SBMTE) in human urine as a means of assessing exposure to HD. The method used immobilized liquid-liquid extraction with diatomaceous earth, followed by the analysis of the urine extract using isotope-dilution gas chromatography-tandem mass spectrometry. Relative standard deviations were less than 8.6% at 1 ng/mL and 3.6% at 20 ng/mL. The limit of detection for SBMTE was 0.038 ng/mL in 0.5 mL of urine.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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