Journal Article

Analysis of the Sulfur Mustard Metabolite 1,1′-Sulfonylbis[2-<i>S</i>-(<i>N</i>-acetylcysteinyl)ethane] in Urine by Negative Ion Electrospray Liquid Chromatography-Tandem Mass Spectrometry

Robert W. Read and Robin M. Black

in Journal of Analytical Toxicology

Volume 28, issue 5, pages 352-356
Published in print July 2004 | ISSN: 0146-4760
Published online July 2004 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/28.5.352
Analysis of the Sulfur Mustard Metabolite 1,1′-Sulfonylbis[2-S-(N-acetylcysteinyl)ethane] in Urine by Negative Ion Electrospray Liquid Chromatography-Tandem Mass Spectrometry

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A method is described for the analysis of the sulfur mustard metabolite 1,1′-sulfonylbis[2-S-(N-acetylcysteinyl)ethane] in human urine. The analyte was concentrated from urine on a polymeric SPE cartridge and analyzed by liquid chromatography-negative ion electrospray tandem mass spectrometry in the selected reaction monitoring mode. The limit of detection was 0.5–1 ng/mL. The metabolite was detected at concentrations close to the detection limit in samples of urine from two casualties accidentally exposed to sulfur mustard from a First World War munition.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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