Journal Article

Isotope Dilution-Mass Spectrometry Determination of Blood Cyanide by Headspace Gas Chromatography

Pierre Dumas, Guy Gingras and Alain LeBlanc

in Journal of Analytical Toxicology

Volume 29, issue 1, pages 71-75
Published in print January 2005 | ISSN: 0146-4760
Published online January 2005 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/29.1.71
Isotope Dilution-Mass Spectrometry Determination of Blood Cyanide by Headspace Gas Chromatography

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A direct and sensitive method for the determination of blood cyanide by isotope dilution was developed. The blood is placed in a headspace vial, and K13C15N is added as internal standard. Addition of phosphoric acid liberates the cyanide as HCN. The detection is accomplished by mass spectrometry after a fine mass calibration tuning. The detection limit obtained is 0.3 µmol/L. The within- and inter-run coefficients of variation are 4.4% (for a concentration of 2.5 µmol/L) and 3.9% (for a concentration of 4.7 µmol/L), respectively. The observed recovery is 98%. A round-robin exercise was carried out to compare the performance of this method with others currently in use in other clinical laboratories.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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