Journal Article

Quantification of 2,4-D on Solid-Phase Exposure Sampling Media by LC-MS-MS

M. Gardner, M. Spruill-McCombs, J. Beach, L. Michael, K. Thomas and R.S. Helburn

in Journal of Analytical Toxicology

Volume 29, issue 3, pages 188-192
Published in print April 2005 | ISSN: 0146-4760
Published online April 2005 | e-ISSN: 1945-2403 | DOI:
Quantification of 2,4-D on Solid-Phase Exposure Sampling Media by LC-MS-MS

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  • Medical Toxicology
  • Toxicology (Non-medical)


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Three types of solid-phase chemical exposure sampling media: cellulose, polyurethane foam, and XAD-2, were analyzed for 2,4-dichlorophenoxyacetic acid (2,4-D) and the amine salts of 2,4-D. Individual samples were extracted into acidified methanol, and the extracts were analyzed via liquid chromatography-tandem mass spectrometry using electrospray ionization and a C8 reversed-phase LC column. 13C 2,4-D and a labeled benzoic acid (13C or d5) were employed as the surrogate and internal standard, respectively. Over a three-year study of pesticide exposure among agricultural workers involving a high volume of analyses, values of average % recovery for 13C 2,4-D on personal exposure samples ranged from 87 to 98 with a % relative standard deviation ranging from 7 to 12. The performance of the method compares favorably with that of the current National Institute for Occupational Safety and Health-recommended approach for the analysis of 2,4-D on these types of exposure sampling matrices.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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