Journal Article

Gas Chromatography-High-Resolution Mass Spectrometric Method for Determination of Methamphetamine and its Major Metabolite Amphetamine in Human Hair

Jin Young Kim, Sung Ill Suh, Moon Kyo In and Bong Chul Chung

in Journal of Analytical Toxicology

Volume 29, issue 5, pages 370-375
Published in print July 2005 | ISSN: 0146-4760
Published online July 2005 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/29.5.370
Gas Chromatography-High-Resolution Mass Spectrometric Method for Determination of Methamphetamine and its Major Metabolite Amphetamine in Human Hair

More Like This

Show all results sharing these subjects:

  • Medical Toxicology
  • Toxicology (Non-medical)

GO

Show Summary Details

Preview

Gas chromatography-high-resolution mass spectrometric (GC-HRMS) method is presented for the qualitative and quantitative analysis of methamphetamine (MA) and its major metabolite, amphetamine (AMP), in human hair. The method procedure involves decontamination of hair with distilled water and acetone, acidic hydrolysis and extraction in the presence of the internal standard, and GC-HRMS selective ion monitoring (SIM) analysis. The limits of detection (LOD) were 9 pg/mg for MA and 21 pg/mg for AMP using a 30-mg hair sample, and the SIM responses were linear with coefficients of correlation ranged from 0.9998 to 0.9999. The recoveries were found to be 91.1–92.3%. By using HRMS (resolution of 5000), detection sensitivity is improved because of the elimination of the biological background, and the LODs for MA and AMP were 2.4–4.4 times lower than those of low-resolution MS. The GC-HRMS method was successfully applied to the analysis of cosmetically treated hair, which is difficult to analyze with the conventional method.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.