Journal Article

Determination of 1,1,1,2,3,3,3-Heptafluoropropane (HFP) in Blood by Headspace Gas Chromatography-Mass Spectrometry

Volker Auwärter, Hans Proquitté, Gerd Schmalisch, Roland Wauer and Fritz Pragst

in Journal of Analytical Toxicology

Volume 29, issue 6, pages 574-576
Published in print September 2005 | ISSN: 0146-4760
Published online September 2005 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/29.6.574
Determination of 1,1,1,2,3,3,3-Heptafluoropropane (HFP) in Blood by Headspace Gas Chromatography-Mass Spectrometry

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The inert and certified medical gas 1,1,1,2,3,3,3-heptafluoropropane (HFP) is commonly used as a propellant in medical sprays. HFP is also of interest as tracer gas for lung function measurements. In this work a sensitive method for quantitative determination of HFP in blood was developed using headspace gas chromatography-mass spectrometry with N2 as internal standard. The limits of detection and quantification were 0.005 and 0.016 mg/L, respectively. The method was applied to blood samples from newborn piglets that were ventilated with air containing 0.8% HFP (v/v) for 30 min. This was done to assess accumulation of HFP during measurement of functional residual lung capacity by wash-in and wash-out techniques. A saturation concentration in blood between 2.0 and 2.5 mg/L was attained after 3 min ventilation and decreased with a half-life below 1 min after termination of the HFP supply. No relevant accumulation of HFP was observed.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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