Journal Article

Determination of <i>I</i>-Methamphetamine: A Case History

John F. Wyman and John T. Cody

in Journal of Analytical Toxicology

Volume 29, issue 7, pages 759-761
Published in print October 2005 | ISSN: 0146-4760
Published online October 2005 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/29.7.759
Determination of I-Methamphetamine: A Case History

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Methamphetamine was detected in a 77-year-old male who had a history of congestive heart failure. Using a modification of a previously reported method, trifluoroacetyl-l-prolyl chloride was used to derivatize sympathomimetic amines to allow separation and identification of individual enantiomers. The I-enantiomer of methamphetamine and a trace amount of I-amphetamine were found in blood and urine specimens from this case. Further investigation revealed the decedent had bronchial asthma and regularly used a Vicks® Inhaler, which contains I-methamphetamine as the active ingredient.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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