Journal Article

Detection of Recombinant Epoetin and Darbepoetin Alpha after Subcutaneous Administration in the Horse

Françoise Lasne, Marie-Agnes Popot, Emmanuelle Varlet-Marie, Laurent Martin, Jean-Antoine Martin, Yves Bonnaire, Michel Audran and Jacques de Ceaurriz

in Journal of Analytical Toxicology

Volume 29, issue 8, pages 835-837
Published in print November 2005 | ISSN: 0146-4760
Published online November 2005 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/29.8.835
Detection of Recombinant Epoetin and Darbepoetin Alpha after Subcutaneous Administration in the Horse

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A direct detection method for anti-doping control of recombinant human erythropoietin (rHuEPO) abuse in racehorses is proposed. This method involves screening of plasma (or serum) by an enzyme-linked immunosorbent assay specific for human EPO and confirmation in urine samples by characterization of the urinary EPO isoelectric profile. This method was tested on horses that were administered epoetin alpha (rHuEPO) and the hyperglycosylated form of this drug (darbepoetin alpha).

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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