Journal Article

Two Cases of Fatal Amlodipine Overdose*

Jason H. Sklerov, Barry Levine, Kathleen M. Ingwersen, Patricia A. Aronica-Pollack and David Fowler

in Journal of Analytical Toxicology

Volume 30, issue 5, pages 346-350
Published in print June 2006 | ISSN: 0146-4760
Published online June 2006 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/30.5.346
Two Cases of Fatal Amlodipine Overdose*

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Two fatal overdoses of the calcium channel blocker amlodipine are described. Postmortem samples were screened for volatiles and therapeutic and abused drugs. Amlodipine was measured by liquid chromatography-atmospheric pressure photoionization-mass spectrometry. The heart blood amlodipine concentrations for the two cases were 2.4 and 0.95 mg/L, and amlodipine was quantified in all other tissues. In the first case, venlafaxine and norvenlafaxine were also found, and the angiotensin receptor antagonist olmesartan was tentatively identified. The concentrations of amlodipine are compared with previously reported fatal and nonfatal overdoses. The medical examiners ruled in both cases that the manner of death was suicide and the causes of death were mixed drug intoxication and amlodipine intoxication.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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