Journal Article

Postmortem Memantine Concentrations

Nichole Bynum, Justin Poklis, Diana Garside and Ruth Winecker

in Journal of Analytical Toxicology

Volume 31, issue 4, pages 233-236
Published in print May 2007 | ISSN: 0146-4760
Published online May 2007 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/31.4.233
Postmortem Memantine Concentrations

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Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. Blood concentrations ranged from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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