Journal Article

Multianalyte Quantification of Five Sesqui- and Ethyl Ether Oxy-Mustard Metabolites in Human Urine by Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry

Doris H. Ash, Sharon W. Lemire, Sara C. McGrath, Lisa G. McWilliams and John R. Barr

in Journal of Analytical Toxicology

Volume 32, issue 1, pages 44-50
Published in print January 2008 | ISSN: 0146-4760
Published online January 2008 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/32.1.44
Multianalyte Quantification of Five Sesqui- and Ethyl Ether Oxy-Mustard Metabolites in Human Urine by Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry

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Sesqui- and oxy-mustards pose a significant threat to military forces and civilians because they are potent vesicants. We have developed an isotope-dilution high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry method utilizing negative ion multiple reaction monitoring for the analysis of sesqui-mustard metabolites bis(2-hydroxyethylthio)alkanes (n = 1–5) and oxy-mustard metabolite bis(2-hydroxyethylthioethyl)ether in human urine. Relative standard deviations were < 10% and the reportable limits of detection were 1 ng/mL in 0.5 mL of urine. We applied this method to 100 samples collected from individuals with no known exposure to sesqui- or oxy-mustards, and no urines showed detectable levels of any of the analytes, suggesting that these metabolites may be used for monitoring exposure to sesqui- and oxy-mustards.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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