Journal Article

Cannabinoid Concentrations in Spot Serum Samples 24–48 Hours After Discontinuation of Cannabis Smoking

Gisela Skopp and Lucia Pötsch

in Journal of Analytical Toxicology

Volume 32, issue 2, pages 160-164
Published in print March 2008 | ISSN: 0146-4760
Published online March 2008 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/32.2.160
Cannabinoid Concentrations in Spot Serum Samples 24–48 Hours After Discontinuation of Cannabis Smoking

More Like This

Show all results sharing these subjects:

  • Medical Toxicology
  • Toxicology (Non-medical)

GO

Show Summary Details

Preview

A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24–48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During sampling, distinctive effects due to drug use could not be observed. The randomly collected samples from heavy (n = 16, > 1 joint/day), moderate (n = 15, ≤ 1 joint/day), and light (n = 6, < 1 joint/week) users of cannabis were analyzed for THC, 11-hydroxy-THC (OH-THC), and free 11-nor-9-carboxy-THC (THCCOOH) by gas chromatography-mass spectrometry as well as for glucuronidated THCCOOH by liquid chromatography-tandem mass spectrometry. THC was detectable in 9, 6, and 1 samples from heavy, moderate, and light users, respectively. Although cannabinoid concentrations were overlapping between groups, there was a trend towards higher concentrations of both conjugated and free THCCOOH in regular users compared to occasional users. The present findings appear to indicate that low levels of THC, or of THC along with OH-THC, may not unequivocally prove a very recent use of cannabis.

Journal Article.  0 words. 

Subjects: Medical Toxicology ; Toxicology (Non-medical)

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.