Journal Article

Comparison of Zopiclone Concentrations in Oral Fluid Sampled with Intercept<sup>®</sup> Oral Specimen Collection Device and Statsure Saliva Sampler™ and Concentrations in Blood

Hallvard Gjerde, Elisabeth L. Øiestad, Åse Marit L. Øiestad, Marit Langødegård, Ingebjørg Gustavsen, Knut Hjelmeland, Jean-Paul Bernard and Asbjørg S. Christophersen

in Journal of Analytical Toxicology

Volume 34, issue 9, pages 590-593
Published in print November 2010 | ISSN: 0146-4760
Published online November 2010 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/jat/34.9.590
Comparison of Zopiclone Concentrations in Oral Fluid Sampled with Intercept® Oral Specimen Collection Device and Statsure Saliva Sampler™ and Concentrations in Blood

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A clinical study of zopiclone was performed using doses of 5 and 10 mg. Samples of oral fluid were collected using the Statsure and Intercept devices, and blood samples were collected simultaneously. Concentrations of zopiclone in samples of oral fluid and blood were determined with liquid chromatography-mass spectrometry, and concentrations in undiluted oral fluid were calculated. The concentrations of zopiclone in oral fluid were generally higher when using the Intercept compared to the Statsure device; the median oral fluid/whole blood concentration ratios were 3.8 (range 1.5–15.9) and 1.9 (range 1.2–4.6), respectively (n = 21). The correlation between zopiclone concentrations in oral fluid collected with the two devices was fairly poor, r2 = 0.35. The results indicate that the type of sampling device may significantly affect the analytical result for zopiclone in sampled oral fluid.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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