Journal Article

Determination of Carisoprodol and Meprobamate in Oral Fluid

Cynthia Coulter, Margaux Garnier, James Tuyay, Jonathan Orbita and Christine Moore

in Journal of Analytical Toxicology

Volume 36, issue 3, pages 217-220
Published in print April 2012 | ISSN: 0146-4760
Published online April 2012 | e-ISSN: 1945-2403 | DOI:
Determination of Carisoprodol and Meprobamate in Oral Fluid

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  • Medical Toxicology
  • Toxicology (Non-medical)


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The determination of carisoprodol and its metabolite meprobamate in oral fluid using solid-phase extraction and liquid chromatography with tandem mass spectral detection (LC–MS-MS) and its application to authentic specimens is described. The method employs collection of oral fluid with the Quantisal device, extraction using cation exchange/hydrophobic solid-phase columns, and LC–MS-MS in positive ion electrospray mode. The method was fully validated using various parameters, including selectivity, linearity, accuracy, intra-day and inter-day imprecision, drug recovery from the collection pad, limit of quantitation and matrix effects. The method was applied to both routine research specimens and an authentic specimen taken from an individual prescribed a daily dose of 350 mg carisoprodol following surgery.

Journal Article.  2737 words.  Illustrated.

Subjects: Medical Toxicology ; Toxicology (Non-medical)

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