Journal Article

Shigeru Tsuiki: a pioneer in the research fields of complex carbohydrates and protein phosphatases

Taeko Miyagi, Kunimi Kikuchi and Shinri Tamura

in The Journal of Biochemistry

Published on behalf of The Japanese Biochemical Society

Volume 150, issue 5, pages 483-490
Published in print November 2011 | ISSN: 0021-924X
Published online October 2011 | e-ISSN: 1756-2651 | DOI: http://dx.doi.org/10.1093/jb/mvr045
Shigeru Tsuiki: a pioneer in the research fields of complex carbohydrates and protein phosphatases

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Dr Tsuiki made three major contributions during his illustrious career as a biochemist. First, he developed the procedure for mucin isolation from bovine submaxillary glands. His work became the basis for mucin biochemistry. Second, he identified four distinct molecular species of mammalian sialidase. Subsequent studies based on his work led to the discovery that sialidase plays a unique role as an intracellular signalling factor involved in the regulation of a variety of cellular functions. Finally, he established the molecular basis for the diversity of mammalian protein phosphatases through protein purification and molecular cloning. His work prompted the functional studies of protein phosphatases.

Keywords: cancer research; complex carbohydrate; protein phosphatase; sialidase

Journal Article.  5441 words.  Illustrated.

Subjects: Biochemistry

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