Journal Article

miR-145 promoted anoikis resistance in tumor endothelial cells

Kyoko Hida, Taisuke Kawamoto, Nako Maishi, Masahiro Morimoto, Kosuke Akiyama, Noritaka Ohga, Masanobu Shindoh, Nobuo Shinohara and Yasuhiro Hida

in The Journal of Biochemistry

Volume 162, issue 2, pages 81-84
Published in print August 2017 | ISSN: 0021-924X
Published online May 2017 | e-ISSN: 1756-2651 | DOI: http://dx.doi.org/10.1093/jb/mvx033
miR-145 promoted anoikis resistance in tumor endothelial cells

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Abstract

Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.

Keywords: angiogenesis; anoikis; miR-145; resistance; tumor endothelial cells

Journal Article.  2288 words.  Illustrated.

Subjects: Cell Biology ; Biotechnology ; Biochemistry ; Molecular and Cell Biology

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