Journal Article

Concerted Evolution of Vertebrate <i>CCR2</i> and <i>CCR5</i> Genes and the Origin of a Recombinant Equine <i>CCR5/2</i> Gene

Andrey A. Perelygin, Andrey A. Zharkikh, Natalia M. Astakhova, Teri L. Lear and Margo A. Brinton

in Journal of Heredity

Published on behalf of American Genetic Association

Volume 99, issue 5, pages 500-511
Published in print January 2008 | ISSN: 0022-1503
Published online May 2008 | e-ISSN: 1465-7333 | DOI: https://dx.doi.org/10.1093/jhered/esn029
Concerted Evolution of Vertebrate CCR2 and CCR5 Genes and the Origin of a Recombinant Equine CCR5/2 Gene

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Chemokine receptors (CCRs) play an essential role in the initiation of an innate immune host response. Several of these receptors have been shown to modulate the outcome of viral infections. The recent availability of complete genome sequences from a number of species provides a unique opportunity to analyze the evolution of the CCR genes. A phylogenetic analysis revealed that the CCR2 gene evolved in concert with the paralogous CCR5 gene, but not with another paralogous gene, CCR3, in the opossum, platypus, rabbit, guinea pig, cat, and rodent lineages. In addition, evidence of concerted evolution of the CCR2 and CCR5 genes was observed in chicken and lizard genomes. A unique CCR5/2 gene that originated by unequal crossing over between the CCR2 and CCR5 genes was detected in the domestic horse. The CCR2, CCR5, and CCR5/2 genes were mapped to ECA16q21 using fluorescent in situ hybridization (FISH). Single-nucleotide polymorphisms identified in the equine CCR5 gene and characterized within 5 horse breeds provide haplotype markers for future case/control studies investigating the genetic bases of horse susceptibility to infectious diseases.

Journal Article.  5650 words.  Illustrated.

Subjects: Genetics and Genomics

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