Journal Article

Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice

Akira Ishikawa

in Journal of Heredity

Published on behalf of American Genetic Association

Volume 100, issue 4, pages 501-504
Published in print January 2009 | ISSN: 0022-1503
Published online March 2009 | e-ISSN: 1465-7333 | DOI: http://dx.doi.org/10.1093/jhered/esp004
Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice

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The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis of body weight at 1, 3, 6, and 10 weeks after birth was performed on a population of 265 F2 intercross mice between the developed congenic strain and its background strain C57BL/6J. A significant QTL (named Pbwg1.10) affecting body weight at 6 and 10 weeks of age was identified within an approximately 21-Mb support interval. Surprisingly, Pbwg1.10 had an overdominance effect and caused heterosis for body weight. This result supported the overdominance hypothesis explaining heterosis.

Keywords: body weight; heterosis; mice; overdominance; QTL

Journal Article.  2761 words.  Illustrated.

Subjects: Genetics and Genomics

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