Journal Article

Clinicopathologic and Prognostic Significance of MMP-7 (Matrilysin) Expression in Human Rectal Cancer

Hong-zhi Luo, Zong-guang Zhou, Lie Yang, Yong-yang Yu, Cao Tian, Bing Zhou, Xue-Lian Zheng, Qing-jie Xia, Yuan Li and Rong Wang

in Japanese Journal of Clinical Oncology

Volume 35, issue 12, pages 739-744
Published in print December 2005 | ISSN: 0368-2811
Published online November 2005 | e-ISSN: 1465-3621 | DOI: http://dx.doi.org/10.1093/jjco/hyi195
Clinicopathologic and Prognostic Significance of MMP-7 (Matrilysin) Expression in Human Rectal Cancer

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Objective: There is increasing evidence to indicate that MMP-7 plays a more important role in tumor progression than other MMPs. The aim of this study was to detect MMP-7 expression in human rectal cancer and normal rectal tissue and to determine whether it is correlated with invasion and metastasis of human rectal cancer.

Methods: Eighty-six paired samples of rectal cancer and distant normal rectal tissue obtained from 100 inpatients were allocated into two groups (cancer group and control group). MMP-7 mRNA was detected by relative quantitative real-time RT–PCR and MMP-7 protein was examined by immunohistochemical staining and computerized image analysis.

Results: MMP-7 mRNA expression in cancer group was higher than that in control group (P = 0.006), the expression ratios of 31 samples (37.35%) were <1 and 52 (62.65%) were >1. The mRNA expression level was correlated with Dukes Staging, histological differentiation grade and CEA level. The MMP-7 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in cancer group (1.82 ± 0.03) was different from that in control group (1.17 ± 0.13, P = 0.002). Moreover, in cancer group the positive staining degree in high-level mRNA cancers (2.04 ± 0.18, n = 52) was higher than that in low-level mRNA ones (1.58 ± 0.23, n = 31, P = 0.008).

Conclusions: Our results suggest that MMP-7 plays an important role in the progression of human rectal cancer. MMP-7 may be selected as a clinical diagnosis and prognosis index in rectal cancer.

Keywords: MMP-7; expression; rectal cancer

Journal Article.  3519 words.  Illustrated.

Subjects: Medical Oncology

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