Journal Article

Parathyroid Hormone-related Protein-Secreting Uterine Endometrioid Adenocarcinoma

Yukio Kinugasa, Ken-ichiro Morishige, Shoji Kamiura, Yoshitane Tsukamoto and Fumitaka Saji

in Japanese Journal of Clinical Oncology

Volume 36, issue 2, pages 113-115
Published in print February 2006 | ISSN: 0368-2811
Published online January 2006 | e-ISSN: 1465-3621 | DOI:
Parathyroid Hormone-related Protein-Secreting Uterine Endometrioid Adenocarcinoma

Show Summary Details


The diagnosis of parathyroid hormone-related protein (PTHrP)-secreting metastatic uterine endometrioid cancer was made in a 32-year-old Japanese woman with humoral hypercalcemia of malignancy. The primary endometrial cancer had been removed, and the tumor was diagnosed as Grade 1 endometrioid adenocarcinoma with shallow myometrial invasion. Salvage chemotherapy (paclitaxel and calboplatin) was started from 5 months after surgery when recurrent tumors were detected in the peritoneum and liver. Despite the salvage chemotherapy, the tumor progressed and hypercalcemia became evident with elevated PTHrP whereas no bone metastasis was identified. To the best of our knowledge, this is the first reported case of hypercalcemia due to PTHrP secretion in uterine endometrioid adenocarcinoma.

Keywords: humoral hypercalcemia of malignancy; endometrioid adenocarcinoma; endometrial cancer; parathyroid hormone-related protein

Journal Article.  1187 words.  Illustrated.

Subjects: Medical Oncology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.