Journal Article

Ability of contrast-enhanced ultrasonography to determine clinical responses of breast cancer to neoadjuvant chemotherapy

Ai Amioka, Norio Masumoto, Noriko Gouda, Keiko Kajitani, Hideo Shigematsu, Akiko Emi, Takayuki Kadoya and Morihito Okada

in Japanese Journal of Clinical Oncology

Volume 46, issue 4, pages 303-309
Published in print April 2016 | ISSN: 0368-2811
Published online February 2016 | e-ISSN: 1465-3621 | DOI: http://dx.doi.org/10.1093/jjco/hyv215
Ability of contrast-enhanced ultrasonography to determine clinical responses of breast cancer to neoadjuvant chemotherapy

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  • Clinical Medicine
  • Medical Oncology
  • Clinical Oncology
  • Surgical Oncology

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Objective

We aimed to determine whether contrast-enhanced ultrasonography can predict the effects of neoadjuvant chemotherapy on breast cancer.

Methods

The clinical responses of 63 consecutive patients with breast cancer (T1–4, N0–1, M0) to neoadjuvant chemotherapy between October 2012 and May 2015 were assessed using contrast-enhanced magnetic resonance imaging, positron emission tomography/computed tomography and contrast-enhanced ultrasonography. Perfusion parameters for contrast-enhanced ultrasonography were created from time–intensity curves based on enhancement intensity and temporal changes to objectively evaluate contrast-enhanced ultrasonography findings. The sensitivity, specificity and accuracy of contrast-enhanced ultrasonography, magnetic resonance imaging and positron emission tomography/computed tomography to predict a pathological complete response were compared after confirming the pathological findings of surgical specimens.

Results

Twenty-three (36.5%) of the 63 patients achieved pathological complete response. The sensitivity, specificity and accuracy of contrast-enhanced ultrasonography for predicting pathological complete response were 95.7% (82.5–99.2%), 77.5% (69.9–79.5%) and 84.1% (74.5–86.7%). The sensitivity of contrast-enhanced ultrasonography was significantly greater than that of magnetic resonance imaging (95.7 vs. 69.6%, P = 0.047). The specificity and accuracy were significantly greater and tended to be greater, respectively, for contrast-enhanced ultrasonography than positron emission tomography/computed tomography (specificity, 77.5 vs. 52.5%, P = 0.02; accuracy, 84.1 vs. 69.8%, P = 0.057).

Conclusions

Contrast-enhanced ultrasonography might serve as a new diagnostic modality when planning therapeutic strategies for patients with breast cancer after neoadjuvant chemotherapy.

Keywords: breast cancer; ultrasonography; contrast agents; neoadjuvant therapy; magnetic resonance imaging

Journal Article.  4884 words.  Illustrated.

Subjects: Clinical Medicine ; Medical Oncology ; Clinical Oncology ; Surgical Oncology

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