Journal Article

A Putative Exonic Splicing Polymorphism in the BCL6 Gene and the Risk of Non-Hodgkin Lymphoma

Yawei Zhang, Qing Lan, Nathaniel Rothman, Yong Zhu, Shelia Hoar Zahm, Sophia S. Wang, Theodore R. Holford, Brian Leaderer, Peter Boyle, Bing Zhang, Kaiyong Zou, Stephen Chanock and Tongzhang Zheng

in JNCI: Journal of the National Cancer Institute

Volume 97, issue 21, pages 1616-1618
Published in print November 2005 | ISSN: 0027-8874
Published online November 2005 | e-ISSN: 1460-2105 | DOI:
A Putative Exonic Splicing Polymorphism in the BCL6 Gene and the Risk of Non-Hodgkin Lymphoma

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Recent studies have shown that the B-cell lymphoma 6 gene (BCL6) is an oncogene that contributes to lymphomagenesis. Exon 6 of BCL6 contains a common single nucleotide polymorphism (SNP) (−195 C>T; dbSNP ID: rs1056932) that alters a potential binding site for an exonic splicing enhancer. We used unconditional logistic regression models to examine the association between this SNP and the risk of non-Hodgkin lymphoma (NHL) in a population-based case–control study of women residing in Connecticut (461 case patients and 535 control subjects). The risk of NHL among women with the CC genotype was more than double that of women with the TT genotype (odds ratio [OR] = 2.2, 95% confidence interval [CI] = 1.5 to 3.3). Higher risks were observed for two NHL subtypes, namely B-cell chronic lymphatic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma (OR = 3.5, 95% CI = 1.6 to 7.8) and T-cell lymphoma (OR = 5.2, 95% CI = 2.0 to 13.3). Our results support the hypothesis that a genetic variant that could alter mRNA transcripts of BCL6 may contribute to the etiology of NHL and suggest that this variant warrants further investigation.

Journal Article.  2060 words. 

Subjects: Medical Oncology

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