Journal Article

Diabetes Mellitus and Risk of Colorectal Cancer in the Singapore Chinese Health Study

Adeline Seow, Jian-Min Yuan, Woon-Puay Koh, Hin-Peng Lee and Mimi C. Yu

in JNCI: Journal of the National Cancer Institute

Volume 98, issue 2, pages 135-138
Published in print January 2006 | ISSN: 0027-8874
Published online January 2006 | e-ISSN: 1460-2105 | DOI:
Diabetes Mellitus and Risk of Colorectal Cancer in the Singapore Chinese Health Study

Show Summary Details


The incidence of colorectal cancer is highest in populations that consume an energy-dense diet, have low intakes of vegetables and fruit, or lead a sedentary lifestyle. These factors may influence colorectal carcinogenesis via insulin pathways. We examined whether diabetes mellitus was associated with colorectal cancer in Singapore Chinese, whose body type and lifestyle profiles are distinct from those of Western populations. Between April 1993 and December 1998, 63 257 Singapore Chinese men and women aged 45 to 74 years were enrolled in a prospective study of diet and cancer. Each subject provided dietary, medical, and lifestyle information through an in-person interview. As of December 31, 2002, 636 incident colorectal cancer cases had been diagnosed. A history of physician-diagnosed diabetes was statistically significantly associated with colorectal cancer risk in both men (relative risk [RR] = 1.5, 95% confidence interval [CI] = 1.2 to 2.1) and women (RR = 1.4, 95% CI = 1.0 to 1.9). In stratified analyses, this association remained statistically significant among the subset of diabetics with high total calorie intake and low physical activity levels. Our results support the hypothesis that hyperinsulinemia may play a role in colorectal carcinogenesis, even in a relatively lean population.

Journal Article.  3344 words. 

Subjects: Medical Oncology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.