Journal Article

Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography

Toshihiko INOUE, Norihisa MASAI, Ryoong-Jin OH, Hiroya SHIOMI and Noriyasu HASHIDA

in Journal of Radiation Research

Volume 55, issue 3, pages 502-508
Published in print May 2014 | ISSN: 0449-3060
Published online April 2014 | e-ISSN: 1349-9157 | DOI: http://dx.doi.org/10.1093/jrr/rru023

More Like This

Show all results sharing these subjects:

  • Clinical Genetics
  • Molecular Biology and Genetics
  • Epidemiology
  • Radiology
  • Nuclear Chemistry, Photochemistry, and Radiation

GO

Show Summary Details

Preview

Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for regular follow-up studies. Using information obtained with SS-OCT, we performed intensity-modulated radiotherapy (IMRT) for a patient with choroidal metastasis from breast cancer with more accuracy than had been previously possible. We made replanning adaptive radiotherapy (ART) three times based on the rapid tumor shrinkage detected by weekly assessments with SS-OCT. Accordingly, the planning target volume (PTV) decreased from 1.6 cm3 to 0.61 cm3 (38%), with 0.95 cm3 (59%) and 0.75 cm3 (46%) as intermediate values during the treatment course. The D0.1 cm3 of the right optic nerve was also reduced from 1.70 Gy/fraction to 0.69 Gy/faction, with 1.41 Gy/fraction and 1.29 Gy/fraction as intermediate values. Adaptive replanning IMRT made it possible to perform locally curative treatment of the metastatic choroidal lesion with a higher dose for the PTV, and a lower dose for organs at risk (OARs).

Keywords: adaptive radiotherapy (ART); intensity-modulated radiotherapy (IMRT); optical coherence tomography (OCT); choroidal metastasis

Journal Article.  2837 words.  Illustrated.

Subjects: Clinical Genetics ; Molecular Biology and Genetics ; Epidemiology ; Radiology ; Nuclear Chemistry, Photochemistry, and Radiation

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.