Journal Article

Heavy-ion-induced sucrose radicals investigated using EPR and UV spectroscopy

Kouichi Nakagawa, Yordanka Karakirova and Nicola D. Yordanov

in Journal of Radiation Research

Volume 56, issue 3, pages 405-412
Published in print May 2015 | ISSN: 0449-3060
Published online December 2014 | e-ISSN: 1349-9157 | DOI: http://dx.doi.org/10.1093/jrr/rru108

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The potential use of a sucrose dosimeter for estimating both linear energy transfer (LET) and the absorbed dose of heavy ion and X-ray radiation was investigated. The stable free radicals were produced when sucrose was irradiated with heavy ions, such as helium, carbon, silicon and neon ions, and when the X-ray radiation was similar to the obtained electron paramagnetic resonance (EPR) spectra, which were ∼7 mT wide and composed of several hyperfine structures. In addition, the total spin concentration resulting from heavy-ion irradiation increased linearly as the absorbed dose increased, and decreased logarithmically as the LET increased. These empirical relations imply that the LET at a certain dose can be determined from the spin concentration. For sucrose and alanine, both cross-sections following C-ion irradiation with a 50 Gy dose were ∼1.3 × 10−12 [μm2], taking into account the molecular size of the samples. The values of these cross-sections imply that multiple ionizing particles were involved in the production of stable radicals. Furthermore, UV absorbance at 267 nm of an aqueous solution of irradiated sucrose was found to linearly increase with increasing absorbed dose. Therefore, the EPR and UV results suggest that sucrose can be a useful dosimeter for heavy-ion irradiation.

Keywords: EPR; UV spectrometry; sucrose; radical; heavy ion; irradiation; X-ray; alanine; cross-section; sugar

Journal Article.  4781 words.  Illustrated.

Subjects: Clinical Genetics ; Molecular Biology and Genetics ; Epidemiology ; Radiology ; Nuclear Chemistry, Photochemistry, and Radiation

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