Journal Article

Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation

Masataka Karube, Shinichiro Mori, Hiroshi Tsuji, Naoyoshi Yamamoto, Mio Nakajima, Keiichi Nakagawa and Tadashi Kamada

in Journal of Radiation Research

Volume 57, issue 5, pages 576-581
Published in print September 2016 | ISSN: 0449-3060
Published online September 2016 | e-ISSN: 1349-9157 | DOI: https://dx.doi.org/10.1093/jrr/rrw057

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  • Clinical Genetics
  • Molecular Biology and Genetics
  • Epidemiology
  • Radiology
  • Nuclear Chemistry, Photochemistry, and Radiation

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Carbon-ion beam scanning has not previously been used for moving tumor treatments. We have commenced respiratory-gated carbon-ion radiotherapy (CIRT) in the thoracic and abdominal regions under free-breathing conditions as a clinical trial. This study aimed to investigate this treatment in the lungs in comparison with passive scattering CIRT. Five patients had thoracic tumors treated with carbon-ion scanned beams using respiratory gating. We analyzed the actual treatments and calculated passive scattering treatment plans based on the same planning CT. We evaluated tumor size until 3 months post treatment and each treatment plan regarding dose delivered to 95% of the clinical target volume (CTV-D95), mean lung dose, percentage of lung receiving at least 5 Gy (RBE) (Lung-V5), Lung-V10, Lung-V20, heart maximum dose (Dmax), esophagus Dmax, cord Dmax and skin Dmax. Obvious tumor deterioration was not observed up to 3 months post treatment. The dose evaluation metrics were similar item by item between respiratory-gated scanned CIRT and passive scattering CIRT. In conclusion, scanned beam CIRT provided treatments equivalent to passive scattering CIRT for thoracic tumors. Increased sample numbers and longer-term observation are needed.

Keywords: carbon-ion radiation therapy; thoracic treatment; respiratory phase–controlled scanning beam treatment; clinical trial

Journal Article.  3983 words.  Illustrated.

Subjects: Clinical Genetics ; Molecular Biology and Genetics ; Epidemiology ; Radiology ; Nuclear Chemistry, Photochemistry, and Radiation

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