Journal Article

Hsp90 canalizes developmental perturbation

Despina Samakovli, Aggeliki Thanou, Charalampos Valmas and Polydefkis Hatzopoulos

in Journal of Experimental Botany

Published on behalf of Society for Experimental Biology

Volume 58, issue 13, pages 3513-3524
Published in print October 2007 | ISSN: 0022-0957
Published online October 2007 | e-ISSN: 1460-2431 | DOI: http://dx.doi.org/10.1093/jxb/erm191
Hsp90 canalizes developmental perturbation

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Stochastic processes are intrinsic phenomena that perturb developmental processes. However, the canalization process restricts the magnitude of perturbation and hence the magnitude of morphological variation during development. Heat-shock protein 90 (Hsp90) chaperones are a class of proteins stabilizing a network of ‘client’ proteins that are involved in diverse signal transduction pathways affecting development. Here it is reported that a reduction of Hsp90 gene dose creates canalization perturbations that affect many aspects of Arabidopsis development and results in a plethora of morphological alterations. Hence, Hsp90 restricts stochastic phenomena by minimizing perturbations, thereby canalizing development. It is also shown that morphogenesis is determined by three mutually inter-related parameters: genotype, environment, and time. Hsp90 is involved in the interaction of these three parameters which ultimately affect developmental processes. The amount of phenotypic variation upon the reduction of Hsp90 function could be perceived as adaptive and could have an impact on the evolutionary process.

Keywords: Arabidopsis; genetic analysis; Hsp90; phenotypic variation; stochastic development

Journal Article.  6699 words.  Illustrated.

Subjects: Plant Sciences and Forestry

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