Chapter

Wilson's disease

Ivan Donaldson, C. David Marsden, Susanne A. Schneider and Kailash P. Bhatia

in Marsden's Book of Movement Disorders

Published on behalf of Oxford University Press

ISBN: 9780192619112
Published online January 2012 | e-ISBN: 9780199698103 | DOI: http://dx.doi.org/10.1093/med/9780192619112.003.0440
Wilson's disease

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WD is a syndrome characterized by a progressive neurological condition which is dominated by a variety of movement disorders, associated with liver disease, caused by copper poisoning due to failure to excrete copper in bile. It is inherited as an autosomal recessive trait, so there is a one in four possibility that other siblings may be affected. The chances of a patient with WD bearing a child from a heterozygote carrier are very remote. However, WD obviously occurs with greater frequency in consanguineous matings.

Chapter.  20865 words.  Illustrated.

Subjects: Neurology

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