Case 45

Sarah T Pendlebury, Philip Anslow and Peter M Rothwell

in Neurological Case Histories

Published on behalf of Oxford University Press

Published in print February 2007 | ISBN: 9780192631626
Published online November 2012 | e-ISBN: 9780191753121 | DOI:

Series: Oxford Case Histories

Case 45

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A 79-year-old woman described a 1-month history of gradually progressive unpleasant tingling in the hands together with problems fastening buttons and gripping small objects, difficulty walking and unsteadiness. This was associated with short-term memory loss over the preceding few months: she reported difficulty remembering names and playing bridge, although longer-term memory was intact. General examination was unremarkable. MMSE was 25/30 with deficits in short-term recall and orientation. There was small muscle wasting in the hands with mild weakness. Tone was increased in the legs with clonus at the ankles and mild bilateral pyramidal weakness. Reflexes were brisk except for the ankle jerks, which were absent. The left plantar reflex was upgoing. Vibration and position sense were absent at the ankles with definite Rombergism. In addition, there was finger nose ataxia, dysdiadochokinesis and ataxic gait.

Chapter.  869 words. 

Subjects: Neurology

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