Chapter

Coagulopathy and Vascular Malformations

Denise M. Adams and Ellis J. Neufeld

in Mulliken and Young's Vascular Anomalies

Published on behalf of Oxford University Press

Published in print August 2013 | ISBN: 9780195145052
Published online November 2013 | e-ISBN: 9780199357147 | DOI: https://dx.doi.org/10.1093/med/9780195145052.003.0017
Coagulopathy and Vascular Malformations

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  • Surgery
  • Histopathology
  • Haematology

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Some patients with vascular anomalies are at increased risk for hematological complications, such as hemorrhage, thrombosis or a combination of both. These coagulopathies are presumably secondary to slow and irregular blood flow, large size of anomalous channels, and inadequate production of clotting or anticoagulant factors by abnormal endothelium. Serious embolic or bleeding complications more often occur after surgical or invasive radiological procedures in a small percentage of these patients. The incidence of these coagulopathic abnormalities is not well-documented and their pathogenesis is poorly understood. Furthermore, coagulopathy in vascular anomalies is often mistakenly labeled in the literature, thus perpetuating misdiagnosis and mismanagement. Certain types of vascular anomalies have a higher risk of coagulopathy; these patients may need to be treated with medications such as low molecular weight heparin prior to and after procedures or after thrombotic events. The guidance of a trained hematologist is important for the care of these patients.

Chapter.  5599 words.  Illustrated.

Subjects: Surgery ; Histopathology ; Haematology

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