J. Craig Henry and Robert A. Gross

in Principles of Drug Therapy in Neurology

Second edition

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780195146837
Published online April 2013 | e-ISBN: 9780199322961 | DOI:

Series: Contemporary Neurology Series


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There are several goals of this chapter. We first present a brief classification of seizure types and review the pathophysiology of partial and generalized seizure syndromes. Next, we review the drugs themselves, emphasizing mechanisms of action, indication, pharmacological properties, and interactions, with therapeutic guidelines. Finally, we will consider areas beyond efficacy that constitute special challenges in pharmacotherapy such as treatment of women, including pregnancy; bone health; treatment considerations with elderly patients; treatment of those with coexisting psychiatric disease; the treatment of people with developmental disabilities; and treatment of status epilepticus. Since the previous edition of this monograph, the pharmacological armamentarium for treatment of seizures has more than doubled. This greater variety of choice is offset by the challenge of being familiar with a greater number of medications and their properties.

Chapter.  44950 words.  Illustrated.

Subjects: Neurology

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