Stephen J. Peroutka

in Principles of Drug Therapy in Neurology

Second edition

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780195146837
Published online April 2013 | e-ISBN: 9780199322961 | DOI:

Series: Contemporary Neurology Series


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Migraine is a specific neurological syndrome that has a wide variety of manifestations. At the most basic level, migraine without aura can be defined as a throbbing (usually unilateral) headache with associated nausea. A prodromal phase may last as long as 24 hours before the headache and may consist of mood and appetite changes. Migraine with aura is usually preceded or accompanied by a focal neurological event. The aura is most commonly experienced as a visual alteration but may involve sensory and/or motor changes. Auras may also occur without an associated headache. The headache itself is often accompanied by photophobia, hyperacusis, polyuria, and/or diarrhea. A migraine attack usually lasts from hours to days and is followed by prolonged pain-free intervals. The headache frequency is extremely variable but usually ranges from 1–2 per year to 1–4 per month. The International Headache Society (IHS) has developed specific detailed criteria for the diagnosis of migraine and other types of headaches.2 This chapter is intended to provide a review of the current state of knowledge concerning the biological basis and treatment of migraine.

Chapter.  12715 words. 

Subjects: Neurology

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