Chapter

Ischemic Stroke

Michael Jacewicz, Thaddeus S. Nowal, Elias A. Giraldo and William A. Pulsinelli

in Principles of Drug Therapy in Neurology

Second edition

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780195146837
Published online April 2013 | e-ISBN: 9780199322961 | DOI: http://dx.doi.org/10.1093/med/9780195146837.003.0291

Series: Contemporary Neurology Series

Ischemic Stroke

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Treatment of ischemic stroke presents a formidable challenge. Interventions targeting the known intravascular mechanisms that underlie stroke pathology (thrombolytic, anticoagulant, and antiplatelet therapies) are of demonstrable benefit. Neuroprotective strategies attempting to blunt or reverse cellular mechanisms of tissue damage, although promising in experimental studies, remain clinically unsuccessful. We review in the initial sections the biology of ischemic injury and intravascular mechanisms contributing to clinical stroke, including several important issues in stroke modeling that affect drug development. We then consider specific drug therapies in use or under evaluation for acute stroke, and finally present a current guide to acute stroke management.

Chapter.  20009 words.  Illustrated.

Subjects: Neurology

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